The OPROrefresh mouthguard cleaning tablets have been formulated to help remove stains and kill the bacteria that build up in your mouthguard and will leave it with a fresh minty taste. The OPROrefresh can be used on any mouthguard. The instructions are included but you simply brush the mouthguard under running water with a toothbrush. Add 1 tablet to a glass of warm tap water. Place the mouthguard into the effervescing solution. Leave the mouthguard to soak for 15 minutes. Turn mouthguard over and soak for another 15 minutes. Rinse the mouthguard under running water. Dry and store and you are ready to go. Each box includes 20 tablets.